Structural pattern matching of nonribosomal peptides

De Novo Sequencing of Nonribosomal Peptides

While nonribosomal peptides (NRPs) are of tremendous pharmacological importance, there is currently no technology capable of highthroughput sequencing of NRPs. Difficulties in sequencing NRPs slow down the progress in elucidating the non-ribosomal genetic code and negatively affect various screening programs aimed at the discovery of natural compounds of medical importance. We propose to employ...

NORINE: a database of nonribosomal peptides

Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent pathway called NRP synthesis allows peptide production. It is performed by huge protein complexes called nonribosomal peptide synthetases (NRPSs). The molecules synthesized by NRPS contain a hig...

Inexact graph recognition matching for structural pattern

This paper is concerned with the inexact matching of attributed, relational graphs for structural pattern recognition. The matching procedure is based on a state space search utilizing heuristic information. Some experimental results are reported.

Designing Pattern Matching Algorithms by Exploiting Structural Pattern Properties

Learning from nature's drug factories: nonribosomal synthesis of macrocyclic peptides.

With the discovery of penicillin as an efficient antibacterial agent isolated from the fungus Penicillium notatum, microorganisms attracted considerable attention as a new source for pharmaceutical agents. Screening of microbial extracts revealed the large structural diversity of natural compounds with broad biological activities, such as antimicrobial, antiviral, immunosuppressive, and antitum...